This paper is an interview with Vladimir M. Alpatov, Doctor of Philology, full member of the Russian Academy of Sciences, distinguished linguist, and expert on Japanese studies. The focus of the interview is intercultural communication and the problems associated with translating languages and cultural realities. The difference between cultures makes it necessary to provide extensive commentaries to make the text comprehensive to foreign readers. Though, Vladimir M. Alpatov notes, the comments depend on the purposes and types of translation, such as academic or literary translation. Symbols are part of a greater symbolic and cultural system. Often it is not the symbol but one’s attitude towards the object that causes misunderstanding and requires clarification. Vladimir A. Alpatov gives many examples of how the Japanese view and treat life differently from Russian people. Many discrepancies come from domestic life and economic practices: the Japanese are less knowledgeable about cattle than many other nations. At the same time, insects that are found all around the world receive special treatment and admiration. Vladimir A. Alpatov makes a critical point on the absence of a proper method of studying cultural differences. We observe and list numerous cultural differences, but explanations and theories we come up with have no solid methodological basis. Another topic discussed is machine translation and AI Linguistics used to be considered exact science that implied the possibility of machine translation not assisted by humans. However, it did not happen yet, and the need for human-to-human translation or post-editing is obvious. With literary translation and translation from unrelated languages, the case against AI is stronger — human intuition in translating cultural specifics is indispensable, and various translations rather than a single canonic one should be welcome. Differentiation of sciences brought about cultural studies and linguistic-cultural studies that finally embraced the study of language as one of the vital elements of culture. Today many students study foreign languages and are interested in intercultural communication. They need to learn that we can overcome bias and prejudices through personal contact. One more way to promote a different vision of one’s culture and country — is to speak about it in an understandable language, for example, on the Internet.